This study demonstrates that while hypocalcemia occurs early and consistently in both models of trauma-hemorrhage, simple calcium repletion is insufficient to improve survival. The lack of additional benefit from calcium supplementation when combined with life-saving plasma suggests that the underlying pathophysiology is more complex than a simple calcium deficit. Future strategies must look beyond mere repletion, investigate other primary drivers of trauma-induced hypocalcemia, and optimize the dosing of calcium supplementation.
Walsh et al. (Sun,) studied this question.
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