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April 1, 2026Transfusion

Mapping ionized calcium levels and evaluating the outcome of prehospital calcium supplementation in acute trauma and hemorrhagic shock

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Authors

RWRichard W. WalshThe University of Texas Health Science Center at San AntonioMMMichael A. MeledeoThe University of Texas Health Science Center at San AntonioSNSusannah E. NicolsonThe University of Texas Health Science Center at San Antonio

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Implication

Demonstrates the limited effectiveness of calcium supplementation in improving survival during trauma-induced shock, indicating further investigation is needed.

Key Points

  • The aim is to assess the impact of calcium supplementation on survival in trauma and hemorrhagic shock.
  • Examined ionized calcium levels in trauma-hemorrhage models.
  • Evaluated the effects of calcium repletion alongside plasma therapy.
  • Investigated underlying mechanisms of trauma-induced hypocalcemia.
  • Hypocalcemia was consistently observed in trauma-hemorrhage models.
  • Simple calcium supplementation did not significantly improve survival rates.
  • The combination of calcium supplementation and plasma did not yield additional benefits.

Cite This Study

Walsh et al. (2026) studied this question.

synapsesocial.com/papers/69ccb79916edfba7beb89ab5https://doi.org/10.1111/trf.70176
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