The P23H Rhodopsin Mouse Model Reveals a Novel Interaction Between the Endoplasmic Reticulum and Connecting Cilium Rootlet Within Photoreceptors

Key Points

• The aim is to investigate the interaction between the endoplasmic reticulum and the connecting cilium rootlet in photoreceptors using the P23H rhodopsin mouse model.
• Utilized the P23H rhodopsin mouse model to study photoreceptor architecture.
• Analyzed the role of the connecting cilium rootlet in supporting the endoplasmic reticulum.
• Examined membrane contact sites formed by the endoplasmic reticulum with other membranes.
• The rootlet acts as a scaffold that organizes intracellular structures.
• It is essential for proper positioning of the endoplasmic reticulum within photoreceptors.
• Branching of the endoplasmic reticulum is facilitated by its interaction with the rootlet.