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April 9, 2010Clinical Chemistry386 citationsOpen Access

Seven Direct Methods for Measuring HDL and LDL Cholesterol Compared with Ultracentrifugation Reference Measurement Procedures

WMW. Greg MillerGMGary L. MyersISIkunosuke Sakurabayashi

Key Points

  • To evaluate the performance and analytical accuracy of direct HDL-C and LDL-C measurement methods against reference ultracentrifugation procedures in both nondiseased and diseased individuals.
  • Evaluated direct measurement methods for HDL-C and LDL-C in comparison to ultracentrifugation reference measurement procedures.
  • Assessed assay performance against National Cholesterol Education Program (NCEP) total error goals in diseased and nondiseased subjects.
  • Six of 8 direct HDL-C methods and 5 of 8 direct LDL-C methods met NCEP total error goals in nondiseased individuals.
  • All direct HDL-C and LDL-C methods failed to meet NCEP total error goals in diseased individuals due to a lack of specificity toward abnormal lipoproteins.

Abstract

Six of 8 HDL-C and 5 of 8 LDL-C direct methods met the National Cholesterol Education Program total error goals for nondiseased individuals. All the methods failed to meet these goals for diseased individuals, however, because of lack of specificity toward abnormal lipoproteins.

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Cite This Study

Miller et al. (2010) studied this question.

synapsesocial.com/papers/69d56b3b75589c71d767c98chttps://doi.org/10.1373/clinchem.2009.142810
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