Comparative validation study reveals direct HDL and LDL assays fail accuracy goals in diseased populations, indicating poor specificity toward abnormal lipoproteins.
Six of 8 HDL-C and 5 of 8 LDL-C direct methods met the National Cholesterol Education Program total error goals for nondiseased individuals. All the methods failed to meet these goals for diseased individuals, however, because of lack of specificity toward abnormal lipoproteins.
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Miller et al. (2010) studied this question.
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