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March 31, 2003Circulation758 citationsOpen Access

Plasma Concentrations and Genetic Variation of Matrix Metalloproteinase 9 and Prognosis of Patients With Cardiovascular Disease

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SBStefan BlankenbergHRHans J. RupprechtOPOdette Poirier

Key Points

  • To evaluate plasma MMP-9 concentrations as a predictor of cardiovascular mortality in coronary artery disease patients.
  • Assessment of plasma MMP-9 concentration alongside other inflammatory markers in a clinical setup.
  • Comparison of MMP-9 predictive value for mortality against existing markers.
  • Plasma MMP-9 concentration was associated with increased cardiovascular mortality.
  • The study suggests that MMP-9 may offer independent prognostic information alongside other markers.

Abstract

Plasma MMP-9 concentration was identified as a novel predictor of CV mortality in patients with coronary artery disease. Whether it provides independent prognostic information compared with other inflammatory markers will have to be additionally assessed.

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Cite This Study

Blankenberg et al. (2003) studied this question.

synapsesocial.com/papers/69d667a18232fb1f1d31aff3https://doi.org/10.1161/01.cir.0000058700.41738.12
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