ISO-MSC-Exos showed superior efficacy compared with MSC-Exos in restoring ovarian function and inhibiting ferroptosis, suggesting that ISO pretreatment enhances the therapeutic effect of MSC-Exos in the POF model. Proteomic data provided supportive mechanistic insights into this enhanced efficacy, with the key pathways identified requiring subsequent functional validation.
Zhang et al. (Tue,) studied this question.