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April 10, 2026Stem Cell Research & Therapy0 citationsOpen Access

Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inhibiting ferroptosis in chemotherapy-induced POF

QZQiang ZhangJYJinyu YuYZYan Zheng

Key Points

  • The aim is to evaluate how isorhamnetin-preconditioned MSC-derived exosomes improve ovarian function and inhibit ferroptosis in a model of chemotherapy-induced POF.
  • Comparison of isorhamnetin-preconditioned MSC-derived exosomes with conventional MSC-derived exosomes
  • Assessment of ovarian function restoration
  • Analysis of ferroptosis inhibition
  • Proteomic analysis to identify key mechanistic pathways
  • ISO-MSC-Exos demonstrated greater efficacy than MSC-Exos in restoring ovarian function
  • Inhibition of ferroptosis was significantly enhanced with ISO pretreatment
  • Proteomic data identified key pathways needing further validation

Abstract

ISO-MSC-Exos showed superior efficacy compared with MSC-Exos in restoring ovarian function and inhibiting ferroptosis, suggesting that ISO pretreatment enhances the therapeutic effect of MSC-Exos in the POF model. Proteomic data provided supportive mechanistic insights into this enhanced efficacy, with the key pathways identified requiring subsequent functional validation.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69d894ec6c1944d70ce05e30https://doi.org/10.1186/s13287-026-04989-4
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