What question did this study set out to answer?

To develop a mild, efficient synthesis of unsaturated esters using aryl carboxylic acids and α, β-dibromo esters.

April 10, 2026

Temperature-Governed Synthesis of Unsaturated Esters via a Domino Reaction of Aryl Carboxylic Acids with α, β-Dibromo Esters

Key Points

To develop a mild, efficient synthesis of unsaturated esters using aryl carboxylic acids and α, β-dibromo esters.
One pot, two steps synthesis
Used aryl carboxylic acids and α, β-dibromo esters
Conducted under mild conditions with various substrates
Analyzed yields ranging from moderate to excellent
Achieved yields of unsaturated esters up to 92%
Synthesis accommodated a broad range of substrate types
Temperature controlled the reaction pathway effectively

Abstract

A one pot, two steps synthesis of unsaturated esters between aryl carboxylic acids and α, β-dibromo esters is developed. This tandem reaction underwent mild conditions with a broad range of substrates scope (up to 28 examples) in moderate to excellent yields (up to 92% yield). The reaction can be easily scaled up and temperature acts as a decisive switch to control the reaction pathway.

Bookmark

Temperature-Governed Synthesis of Unsaturated Esters via a Domino Reaction of Aryl Carboxylic Acids with α, β-Dibromo Esters

Key Points

Abstract

Cite This Study