TNFR1 and TNFR2 have opposing effects on cardiac remodeling in heart failure, highlighting the need for receptor-specific approaches in anti-TNF therapies.
TNFR1 and TNFR2 have disparate and opposing effects on remodeling, hypertrophy, NF-kappaB, inflammation, and apoptosis in HF: TNFR1 exacerbates, whereas TNFR2 ameliorates, these events. However, signaling through both receptors is required to induce diastolic dysfunction and oxidative stress. TNFR-specific effects in HF should be considered when therapeutic anti-TNF strategies are developed.
Hamid et al. (Tue,) studied this question.