March 3, 2009CirculationOpen Access

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

View Full Paper

Ask AI

Bookmark

Population

Heart failure

Design

Preclinical

Authors

THTariq HamidHeart Failure & Transplant YGYan GuShanghai University RORoger V. OrtinesIntegrated BioTherapeutics (United States)

Discussion

Member takes

Implication

Receptor-specific TNF modulation merits preclinical testing in HF; leaves open translation to human outcomes.

Structured PICO

Population

Heart failure

Intervention

TNFR1 and TNFR2 signaling

Outcome

Remodeling, hypertrophy, NF-kappaB, inflammation, apoptosis, diastolic dysfunction, and oxidative stresssurrogate

TNFR1 and TNFR2 have opposing effects on cardiac remodeling in heart failure, highlighting the need for receptor-specific approaches in anti-TNF therapies.

Cite This Study

Hamid et al. (2009) studied this question.

synapsesocial.com/papers/69d89965a5ecc596b5d17cb6 https://doi.org/10.1161/circulationaha.108.802918

Topics

Heart failure HFrEF treatment Myocarditis

View Full Paper

Ask AI

Bookmark

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider