What is the clinical evidence from this study?

Population: Coronary microembolization (n=23). Intervention: Coronary microembolization vs. Saline. Primary outcome: Infarct size (percentage area at risk) (p=<0.05).

What question did this study set out to answer?

This research aims to uncover the complex role of tumor necrosis factor-alpha in coronary microembolization and its effects on myocardial infarction.

December 15, 2006Circulation ResearchOpen Access

Bidirectional Role of Tumor Necrosis Factor-α in Coronary Microembolization

Q: What are the key findings of this study?

Coronary microembolization reduced infarct size compared to controls (18% vs 33%, P<0.05), but this delayed protection was abolished by TNF-alpha antibodies.

Q: What question did this study set out to answer?

This research aims to uncover the complex role of tumor necrosis factor-alpha in coronary microembolization and its effects on myocardial infarction.

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Key result

Coronary microembolization reduced infarct size compared to controls (18% vs 33%, P<0.05), but this delayed protection was abolished by TNF-alpha antibodies.

Why the study?

Does TNF-alpha mediate progressive contractile dysfunction and delayed protection against infarction following coronary microembolization in anesthetized pigs?

Key Points

This research aims to uncover the complex role of tumor necrosis factor-alpha in coronary microembolization and its effects on myocardial infarction.
Intracoronary infusion of microspheres induced coronary microembolization in anesthetized pigs (n=7).
Comparative control group received saline (n=8) and two groups were treated with TNF-alpha antibodies or placebo (n=4 each).
Myocardial ischemia was induced 6 hours after microembolization, and infarct size was assessed after 2 hours of reperfusion.
Infarct size reduced with microembolization (18+/-4%) compared to controls (33+/-4%, P<0.05).
TNF-alpha antibodies attenuated contractile dysfunction post-microembolization (group 3 at 77+/-5% vs. group 1 at 65+/-4%, P<0.05).
Reduction of infarct size was abolished by TNF-alpha antibodies, showing no significant difference (29+/-3% vs. 35+/-5%).

Structured PICO

Does TNF-alpha mediate progressive contractile dysfunction and delayed protection against infarction following coronary microembolization in anesthetized pigs?

Population

23 anesthetized pigs subjected to coronary microembolization to evaluate the role of TNF-alpha in contractile dysfunction and infarction.

Intervention

Coronary microembolization (ME) induced by intracoronary infusion of microspheres (42 microm; 3000 per mL/min inflow), with or without pretreatment with ovine TNF-alpha antibodies (25 mg/kg body weight) 30 minutes prior

Comparator

Saline or placebo infusion

Outcome

Infarct size (percentage area at risk) determined after 2 hours of reperfusion, and systolic wall thickeningsurrogate

Main Result

Absolute Event Rate: 18% vs 33%

p-value: p=<0.05

In a porcine model of coronary microembolization, TNF-alpha is responsible for both progressive contractile dysfunction and delayed protection against myocardial infarction.

Discussion

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Implication

Implicates TNF-alpha in porcine microembolization effects; hypothesis-generating for human cardioprotection, requiring clinical validation.

Cite This Study

Skyschally et al. (2006) studied Coronary microembolization (n=23). Coronary microembolization vs. Saline was evaluated on Infarct size (percentage area at risk) (p=<0.05). Coronary microembolization reduced infarct size compared to controls (18% vs 33%, P<0.05), but this delayed protection was abolished by TNF-alpha antibodies.

synapsesocial.com/papers/6a5e387544d40cfb0237c7ec https://doi.org/10.1161/01.res.0000255031.15793.86

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Implication

Implicates TNF-alpha in porcine microembolization effects; hypothesis-generating for human cardioprotection, requiring clinical validation.

Bidirectional Role of Tumor Necrosis Factor-α in Coronary Microembolization

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Bidirectional Role of Tumor Necrosis Factor-α in Coronary Microembolization

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider