Key result
Low-dose TNF-alpha reduces myocardial infarct size vs placebo, whereas higher doses offer no protection.
Why the study?
The effect of TNFα administered before ischemia on myocardial infarction size and apoptosis activation is controversial and dose-dependent.
Does pre-ischemic administration of TNF-alpha reduce myocardial infarct size in a porcine model of myocardial infarction?
Does pre-ischemic administration of TNF-alpha reduce myocardial infarct size in a porcine model of myocardial infarction?
p-value: p=<0.05
Low-dose pre-ischemic administration of TNF-alpha reduces myocardial infarct size and apoptosis-related caspase activity in a porcine model, whereas higher doses lose this cardioprotective effect.
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Low-dose TNF-α pre-ischemia reduces experimental infarct size while high-dose does not; hypothesis-generating for dose-specific effects.
Quang et al. (2013) studied Myocardial infarction (porcine model). TNF-alpha vs. Placebo (normal saline) was evaluated on Myocardial infarct size as a percentage of the area at risk (p=<0.05). Pre-ischemic administration of low-dose TNF-alpha (0.1 and 1 µg/kg) significantly reduced myocardial infarct size compared to placebo, whereas a higher dose (3 µg/kg) offered no protection.
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