November 3, 2004Cardiovascular Research

Free radicals trigger TNF?-induced cardioprotection

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Why the study?

Does low-dose TNF alpha reduce infarct size in isolated rat hearts undergoing ischemia/reperfusion?

Structured PICO

Does low-dose TNF alpha reduce infarct size in isolated rat hearts undergoing ischemia/reperfusion?

Population

Isolated rat hearts undergoing 30 min regional ischemia and 120 min of reperfusion

Intervention

Low dose of TNF alpha (0.5 ng/ml) for 7 min followed by 10 min washout prior to ischemia/reperfusion, with or without N-2-mercaptopropionyl glycine (MPG) (1 mM) for 15 min prior to I/R

Comparator

Control isolated rat hearts undergoing ischemia/reperfusion alone

Outcome

Infarct size (infarct/area at risk ratio) at the end of the reperfusion periodsurrogate

Low-dose TNF alpha induces cardioprotection against ischemia/reperfusion injury in isolated rat hearts through a mechanism involving free radical production.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for TNF-alpha preconditioning in isolated rat hearts; leaves open clinical translation to human I/R injury.

Cite This Study

Lecour et al. (2004) studied this question.

synapsesocial.com/papers/6a8901bf888d86b74818ba18 https://doi.org/10.1016/j.cardiores.2004.10.003

View Full Paper

Ask AI

Bookmark

Free radicals trigger TNF?-induced cardioprotection

Structured PICO

Discussion

Implication

Cite This Study

Free radicals trigger TNF?-induced cardioprotection

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider