September 18, 2001Circulation

Inhibition of Tumor Necrosis Factor-α Improves Postischemic Recovery of Hypertrophied Hearts

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Why the study?

Does TNF-alpha inhibition improve postischemic contractile function in hypertrophied neonatal rabbit hearts?

Structured PICO

Does TNF-alpha inhibition improve postischemic contractile function in hypertrophied neonatal rabbit hearts?

Population

Neonatal rabbits with aortic banding-induced left ventricular hypertrophy subjected to 45 minutes of ischemia and 30 minutes of reperfusion in a Langendorff perfusion model.

Intervention

Neutralizing anti-rabbit TNF-alpha antibody added to cardioplegia and perfusate solutions, or ceramidase inhibitor N-oleoyl ethanolamine.

Comparator

Untreated hypertrophied hearts and age-matched control rabbit hearts.

Outcome

Postischemic contractile function.surrogate

Inhibition of TNF-alpha signaling improves postischemic contractile function, myocardial energetics, and intracellular calcium handling in a preclinical model of compensated pressure-overload hypertrophy.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

TNF-alpha inhibition merits further preclinical testing in hypertrophy; leaves open any clinical translation from this animal model.

Cite This Study

Stamm et al. (2001) studied this question.

synapsesocial.com/papers/6a7d93f24776ec6335186d5b https://doi.org/10.1161/hc37t1.094851

View Full Paper

Ask AI

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Inhibition of Tumor Necrosis Factor-α Improves Postischemic Recovery of Hypertrophied Hearts

Structured PICO

Discussion

Implication

Cite This Study

Inhibition of Tumor Necrosis Factor-α Improves Postischemic Recovery of Hypertrophied Hearts

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider