What question did this study set out to answer?

This research investigates how tumor necrosis factor (TNF) affects heart muscle function in rats.

June 1, 1992Journal of Trauma and Acute Care Surgery

Tumor Necrosis Factor and Cardiac Function

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Why the study?

Does tumor necrosis factor alter myocardial performance in an isolated rat heart model?

Key Points

This research investigates how tumor necrosis factor (TNF) affects heart muscle function in rats.
Utilized isolated papillary muscle technique and modified Langendorff preparation.
Rats received different doses of TNF or saline, and myocardial function was assessed.
Electrophysiologic measurements and whole-heart perfusions were performed.
Group B showed significantly greater peak tension development and contraction velocity compared to controls (p<0.05).
Both TNF-treated groups had a significant decrease in resting membrane potential (p<0.05).
Early benefits of TNF were followed by later impairment of myocardial performance in whole hearts perfused with TNF-treated serum (p<0.05).

Structured PICO

Does tumor necrosis factor alter myocardial performance in an isolated rat heart model?

Population

Male adult rats

Intervention

Tumor necrosis factor (TNF) 100 ng/kg or 100 micrograms/kg, and serum from TNF-treated animals

Comparator

Saline (control)

Outcome

Myocardial performance (peak tension development, velocity of contraction, and contractility)surrogate

Tumor necrosis factor exerts a biphasic effect on myocardial function in rats, with early enhancement followed by later serum-transferable impairment.

Discussion

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Implication

Biphasic TNF effects on rat myocardium warrant no clinical use; leaves open translation and serum factor mechanisms in human HF.

Cite This Study

DeMeules et al. (1992) studied this question.

synapsesocial.com/papers/6a75df2d59d67b3b928b6e4d https://doi.org/10.1097/00005373-199206000-00003

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Tumor Necrosis Factor and Cardiac Function

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Tumor Necrosis Factor and Cardiac Function

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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