Why the study?
Does TNF-alpha acutely alter left ventricular mechanics and energetics in blood-perfused canine hearts?
Population
Nine isolated, blood-perfused canine hearts
Comparison
Recombinant human TNF-alpha infused into the… vs Baseline (before infusion of TNF-alpha)
Design
Preclinical
Follow-up
20 mins
Authors
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May alter myocardial energetics in inflammatory states; leaves open translation to human sepsis or HF.
Does TNF-alpha acutely alter left ventricular mechanics and energetics in blood-perfused canine hearts?
TNF-alpha acutely increases the oxygen cost of contractility in canine left ventricles without significantly altering mechanical contractility, suggesting an effect on excitation-contraction coupling energetics.
Miyano et al. (1999) studied this question.
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