Why the study?
Does tumor necrosis factor-alpha infusion decrease left ventricular contractility in dogs?
Population
12 dogs (n=6 control, n=6 receiving TNF-alpha)
Comparison
Tumor necrosis factor-alpha 60… vs Control dogs
Design
Preclinical
Follow-up
5 hours
Authors
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May implicate TNF-α in sepsis-related myocardial depression; hypothesis-generating in dogs, leaves open human translation.
Does tumor necrosis factor-alpha infusion decrease left ventricular contractility in dogs?
TNF-alpha infusion in dogs causes a rapid decrease in left ventricular contractility, suggesting it acts as an important myocardial depressant factor in sepsis.
Walley et al. (1994) studied this question.
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