Key result
Intracoronary rTNF-alpha increases myocardial microvascular transport and impairs cardiac performance in dogs.
Why the study?
Tumor necrosis factor-alpha is a primary mediator in tissue injury pathogenesis, but its effects on myocardial microvascular transport in vivo were not fully understood.
Does intracoronary recombinant human TNF-alpha increase myocardial microvascular transport and affect cardiac performance in open-chest anesthetized dogs?
Does intracoronary recombinant human TNF-alpha increase myocardial microvascular transport and affect cardiac performance in open-chest anesthetized dogs?
Intracoronary TNF-alpha increases myocardial microvascular permeability and decreases cardiac performance in vivo, highlighting its potential role in myocardial pathophysiology.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications; leaves open TNF-alpha effects on human myocardial microvascular function.
Hansen et al. (1994) studied Myocardial microvascular transport. Intracoronary recombinant human TNF-alpha (rTNF-alpha) was evaluated on Myocardial microvascular transport of a small hydrophilic indicator. Intracoronary infusion of recombinant human TNF-alpha increased myocardial microvascular transport after 120 minutes and induced a prolonged decrease in cardiac performance in dogs.
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