Key result
TNF-knockout mice with aortic banding showed attenuated cardiac apoptosis, hypertrophy, inflammatory response, and reparative fibrosis, and improved cardiac function compared to wild-type mice.
Why the study?
Does TNF-alpha knockout attenuate cardiac remodeling and ventricular dysfunction after pressure overload in mice?
Does TNF-alpha knockout attenuate cardiac remodeling and ventricular dysfunction after pressure overload in mice?
TNF-alpha mediates adverse left ventricular remodeling and ventricular dysfunction during pressure overload, as its absence in knockout mice attenuates these pathological responses.
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TNF-alpha targeting in pressure-overload HF warrants caution; leaves open translation from rodent models to human remodeling.
Sun et al. (2007) studied Pressure overload-induced cardiac remodeling and ventricular dysfunction. TNF-alpha knockout vs. Wild-type was evaluated on Cardiac apoptosis, hypertrophy, inflammatory response, reparative fibrosis, and cardiac function. TNF-knockout mice with aortic banding showed attenuated cardiac apoptosis, hypertrophy, inflammatory response, and reparative fibrosis, and improved cardiac function compared to wild-type mice.
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