November 7, 2000Proceedings of the National Academy of SciencesOpen Access

Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy

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Why the study?

Does anti-TNF-alpha treatment with adenoviral vector expressing soluble TNF-alpha receptor type I improve myocardial matrix remodeling and diastolic function in transgenic mice overexpressing TNF-alpha?

Structured PICO

Population

Transgenic mice with cardiac-specific overexpression of tumor necrosis factor alpha (TNF-alpha) (TNF1.6)

Intervention

Anti-TNF-alpha treatment with adenoviral vector expressing soluble TNF-alpha receptor type I

Outcome

MMP-2 and MMP-9 activity, collagen synthesis, deposition, and denaturation, and myocardial diastolic function (transmitral Doppler echocardiographic E/A wave ratio)surrogate

Anti-TNF-alpha therapy attenuates maladaptive extracellular matrix remodeling and preserves diastolic function in young transgenic mice overexpressing TNF-alpha, suggesting TNF-alpha and MMPs as potential therapeutic targets in heart failure.

Discussion

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Implication

Cautions against clinical use in diastolic HF; leaves open age-specific TNF-α/MMP targeting in human trials.

Cite This Study

Li et al. (2000) studied this question.

synapsesocial.com/papers/6a21436fa2a97f3a085ae04d https://doi.org/10.1073/pnas.97.23.12746

View Full Paper

Ask AI

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Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy

Structured PICO

Discussion

Implication

Cite This Study

Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider