Key result
Tumor necrosis factor triggers expression and activation of MMPs faster and stronger in cardiomyocytes than in cardiofibroblasts via superoxide production and PI3Kgamma activation.
Population
Primary cultures of mouse neonatal cardiomyocytes and cardiofibroblasts; Wild-type and TNF mice subjected to…
Comparison
Recombinant TNF in vitro; cardiac pressure… vs Cardiofibroblasts vs cardiomyocytes; TNF mice vs…
Design
Preclinical
Authors
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May inform preclinical remodeling models; leaves open clinical translation of cardiomyocyte MMP pathways.
TNF induces MMP expression and activation in cardiomyocytes via superoxide and PI3Kgamma, contributing to adverse myocardial remodeling.
Awad et al. (2009) studied Cardiomyopathy / Cardiac pressure overload. Tumor necrosis factor (TNF) vs. Wild-type mice / Cardiofibroblasts was evaluated on MMP expression and activation / superoxide production. Tumor necrosis factor triggers expression and activation of MMPs faster and stronger in cardiomyocytes than in cardiofibroblasts via superoxide production and PI3Kgamma activation.
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