Why the study?
Does MMP inhibition prevent cytokine-induced myocardial contractile dysfunction in isolated rat hearts?
Does MMP inhibition prevent cytokine-induced myocardial contractile dysfunction in isolated rat hearts?
MMP-2 activation mediates cytokine-induced myocardial contractile dysfunction through proteolytic cleavage of troponin I, identifying MMP inhibition as a potential strategy for acute inflammatory heart disease.
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MMP inhibition may preserve function in cytokine-exposed rat hearts; hypothesis-generating for inflammatory cardiomyopathy, needs human validation.
Cindy Q. Gao (2003) studied this question.
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