Why the study?
Does MMP-2 gene ablation exacerbate myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy?
Population
Male and female transgenic mice with cardiac-specific overexpression of TNF-alpha crossed with MMP-2…
Comparison
Ablation of the MMP-2 gene (MMP-2 KO) vs Wild-type MMP-2 (MMP) in the context of…
Design
Preclinical
Authors
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MMP-2 ablation worsens outcomes in this cytokine cardiomyopathy model; leaves open its role in human heart failure.
Does MMP-2 gene ablation exacerbate myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy?
MMP-2 appears to play a cardioprotective role in cytokine-induced cardiomyopathy, as its ablation exacerbates inflammation and cardiac dysfunction in a mouse model.
Matsusaka et al. (2005) studied this question.
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