Key result
Targeted deletion of MMP 2 in mice with chronic pressure overload significantly reduced LV weight/body weight (4.2 vs 5.0 mg/g; P<0.01) and interstitial fibrosis compared to wild-type mice.
Why the study?
Does targeted deletion of the MMP 2 gene ameliorate pressure overload-induced cardiac hypertrophy and dysfunction in mice?
Population
Male MMP 2 knockout mice and sibling wild-type mice subjected to transverse aortic constriction to induce…
Comparison
Targeted deletion of the MMP 2 gene vs Sibling wild-type mice subjected to transverse…
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothesis-generating for MMP2 inhibition in hypertensive heart disease; clinical trials needed before any therapeutic consideration.
Does targeted deletion of the MMP 2 gene ameliorate pressure overload-induced cardiac hypertrophy and dysfunction in mice?
Absolute Event Rate: 4.2% vs 5%
p-value: p=<0.01
Targeted deletion of MMP 2 in mice ameliorates pressure overload-induced left ventricular hypertrophy, dysfunction, and interstitial fibrosis, suggesting MMP 2 inhibition as a potential therapeutic strategy for hypertensive heart disease.
Matsusaka et al. (2006) studied Chronic pressure overload and myocardial remodeling (n=19). Targeted deletion of MMP 2 gene vs. Wild-type (WT) mice was evaluated on Left ventricular (LV) weight/body weight (mg/g) (p=<0.01). Targeted deletion of MMP 2 in mice with chronic pressure overload significantly reduced LV weight/body weight (4.2 vs 5.0 mg/g; P<0.01) and interstitial fibrosis compared to wild-type mice.
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