Why the study?
Does targeted deletion or pharmacological inhibition of MMP-2 prevent cardiac rupture and improve survival in mice after myocardial infarction?
Population
n=45 mice with acute myocardial infarction induced by left coronary artery ligation.
Comparison
Targeted deletion of MMP-2 or pharmacological… vs Vehicle-treated wild-type (WT) mice.
Design
Preclinical, Surviving WT mice were randomly divided into 2 groups
Follow-up
28 days
Authors
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Hypothesis-generating for MMP-2 inhibition to prevent post-MI rupture in mice; human trials needed before any clinical consideration.
Does targeted deletion or pharmacological inhibition of MMP-2 prevent cardiac rupture and improve survival in mice after myocardial infarction?
Targeted deletion or pharmacological inhibition of MMP-2 significantly improves survival after acute myocardial infarction in mice by preventing cardiac rupture and delaying post-MI remodeling.
Matsumura et al. (2005) studied this question.
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