Why the study?
Does a broad-spectrum MMP inhibitor attenuate early left ventricular enlargement after experimental myocardial infarction in mice?
Population
71 male FVB mice that survived ligation of the left anterior coronary artery
Comparison
Broad-spectrum MMP inhibitor administered by… vs Placebo administered by gavage
Design
Preclinical, Randomized
Follow-up
4 days
Authors
Loading...
Attenuates early post-MI left ventricular enlargement in mice; leaves open clinical translation of MMP inhibition.
Does a broad-spectrum MMP inhibitor attenuate early left ventricular enlargement after experimental myocardial infarction in mice?
Inhibition of matrix metalloproteinases attenuates early left ventricular dilation and preserves fractional shortening after experimental myocardial infarction in mice.
Rohde et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: