Key result
Selective MMP inhibition reduces post-MI LV volume by ~17% vs control in a pig model.
Why the study?
Does selective MMP inhibition with PGE-530742 improve left ventricular remodeling post-myocardial infarction in a pig model?
RCT (n=30)
randomized
Does selective MMP inhibition with PGE-530742 improve left ventricular remodeling post-myocardial infarction in a pig model?
Absolute Event Rate: 67% vs 81%
p-value: p=<0.05
Selective MMP inhibition with PGE-530742 attenuated left ventricular dilation and improved regional myocardial geometry post-myocardial infarction in a pig model.
No takes yet. Share an insight, caveat, or question.
Caution against clinical adoption; leaves open whether selective MMP inhibition improves post-MI remodeling in patients.
Apple et al. (2006) conducted an RCT in Myocardial infarction (n=30). Selective MMP inhibitor (PGE-530742) vs. Myocardial infarction-only was evaluated on Left ventricular end-diastolic volume (p=<0.05). Selective MMP inhibition with PGE-530742 attenuated left ventricular dilation post-myocardial infarction compared to control (67 vs 81 mL, P<0.05) in a pig model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: