Why the study?
Does controlled release of MMP-1 plasmid DNA prevent left ventricular remodeling in a rat chronic myocardial infarction model?
Population
Rats with a moderate-sized chronic myocardial infarction (n=42 total; 14 per group)
Comparison
Injection of cationized gelatin microspheres… vs Injection of phosphate buffered saline…
Design
Preclinical, Rats were randomized to 2 groups
Follow-up
4 weeks
Authors
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No immediate clinical implications; hypothesis-generating for MMP-1 delivery in post-MI remodeling.
Does controlled release of MMP-1 plasmid DNA prevent left ventricular remodeling in a rat chronic myocardial infarction model?
Controlled release of MMP-1 plasmid DNA via gelatin microspheres improves cardiac remodeling and function in a rat model of chronic myocardial infarction.
Lin et al. (2009) studied this question.
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