Why the study?
Does cardiac-specific MMP-2 expression directly induce impaired contractility in mice?
Population
8-month-old cardiac-specific, constitutively active MMP-2 transgenic mice and wild-type controls (WT)
Comparison
Cardiac-specific, constitutively active MMP-2… vs Wild-type controls (WT)
Design
Preclinical
Authors
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Suggests MMP-2 impairs myofilament force in mice; hypothesis-generating and should not yet change practice.
Does cardiac-specific MMP-2 expression directly induce impaired contractility in mice?
Cardiac-specific, constitutively active MMP-2 expression directly impairs ventricular contraction and diminishes responses to inotropic stimulation in the absence of superimposed injury.
WANG et al. (2005) studied this question.
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