Key result
Transgenic expression of active MMP-2 in mice induced severe ventricular remodeling and markedly decreased left ventricular ejection fraction (48% vs 78% in controls; P=0.0006).
Why the study?
Does expression of active MMP-2 induce ventricular remodeling and systolic dysfunction in transgenic mice?
Does expression of active MMP-2 induce ventricular remodeling and systolic dysfunction in transgenic mice?
Absolute Event Rate: 48% vs 78%
p-value: p=0.0006
Expression of active MMP-2 in the heart is sufficient to directly induce severe ventricular remodeling and systolic dysfunction.
Authors
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Supports MMP-2 sufficiency for remodeling in mice; leaves open therapeutic targeting in human HF.
Bergman et al. (2006) studied Ventricular remodeling and systolic dysfunction. Transgenic expression of active MMP-2 vs. Control was evaluated on Left ventricular ejection fraction (p=0.0006). Transgenic expression of active MMP-2 in mice induced severe ventricular remodeling and markedly decreased left ventricular ejection fraction (48% vs 78% in controls; P=0.0006).
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