Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction
Population
BALB/c mice (murine coxsackievirus B3 myocarditis model)
Comparison
Viral infection (coxsackievirus B3) vs Sham-infected
Design
Preclinical
Authors
Discussion
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Member takes
Implication
MMP/TIMP imbalance may promote collagen loss and LV dysfunction in viral myocarditis; hypothesis-generating for human translation.
Structured PICO
P
Population
BALB/c mice (murine coxsackievirus B3 myocarditis model)
I
Intervention
Viral infection (coxsackievirus B3)
C
Comparator
Sham-infected
O
Outcome
Myocardial collagen degradation, MMP and TIMP expression (mRNA and protein levels)surrogate
In a murine viral myocarditis model, an imbalance between MMPs and TIMPs leads to collagen degradation, potentially contributing to left ventricular dysfunction.
Cite This Study
LI et al. (2002) studied this question.