Key result
Understanding the intracellular mechanisms controlling matrix metalloproteinase-2 (MMP-2) activity offers a new therapeutic direction for the prevention and treatment of ischemia/reperfusion injury.
Targeting the intracellular regulation of MMP-2 activity represents a potential novel therapeutic strategy to preserve cardiac contractile function following myocardial infarction or ischemia/reperfusion injury.
No takes yet. Share an insight, caveat, or question.
May support targeting intracellular MMP-2 to preserve post-I/R function; hypothesis-generating and requires prospective trials.
Grzegorz Sawicki (2013) conducted a review in Ischemia/reperfusion (I/R) injury and myocardial infarction. Intracellular regulation of MMP-2 activity was evaluated. Understanding the intracellular mechanisms controlling matrix metalloproteinase-2 (MMP-2) activity offers a new therapeutic direction for the prevention and treatment of ischemia/reperfusion injury.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: