Key result
Okadaic acid improved the recovery of mechanical function compared with control ischaemia-reperfusion hearts and prevented the loss of troponin I.
In a rat model of myocardial ischaemia-reperfusion injury, phosphatase inhibition with okadaic acid improved mechanical function and preserved troponin I, suggesting MMP-2 phosphorylation status plays a role in IR injury.
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Should not change clinical practice in ischaemia-reperfusion; hypothesis-generating for phosphatase inhibition in myocardial injury models.
Sarıahmetoğlu et al. (2012) studied Myocardial ischaemia-reperfusion injury. Okadaic acid (OA) vs. Control ischaemia-reperfusion hearts was evaluated on Heart mechanical function, MMP-2 activity and troponin I levels. Okadaic acid improved the recovery of mechanical function compared with control ischaemia-reperfusion hearts and prevented the loss of troponin I.
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