Key result
TNF-alpha knockout mice demonstrated significantly improved cardiac function, with higher fractional shortening from day 1 to 7 post-myocardial infarction compared to wild-type mice.
Why the study?
Does TNF-alpha gene deficiency improve cardiac function and reduce ICAM-1 expression in a mouse model of myocardial infarction?
Does TNF-alpha gene deficiency improve cardiac function and reduce ICAM-1 expression in a mouse model of myocardial infarction?
Absolute Event Rate: 16.5% vs 10.3%
p-value: p=<0.01
TNF-alpha deficiency improves cardiac function and attenuates myocardial remodeling after myocardial infarction in mice by reducing ICAM-1 expression and inflammatory cell infiltration.
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TNF-α inhibition may merit targeted study in post-MI remodeling; leaves open clinical translation from this animal model.
Sato et al. (2006) studied Myocardial Infarction (n=117). TNF-alpha gene knockout vs. Wild-type mice was evaluated on Fractional shortening at 7 days post-myocardial infarction (p=<0.01). TNF-alpha knockout mice demonstrated significantly improved cardiac function, with higher fractional shortening from day 1 to 7 post-myocardial infarction compared to wild-type mice.
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