Can preclinical longitudinal trajectories of nEV biomarkers predict Alzheimer Disease diagnosis?
Preclinical longitudinal trajectories of nEV biomarkers can predict Alzheimer Disease diagnosis, motivating the development of a clinical blood test.
We validated nEV biomarker candidates and further demonstrated that their preclinical longitudinal trajectories can predict AD diagnosis. These findings motivate further development of nEV biomarkers toward a clinical blood test for AD.
Kapogiannis et al. (2019) studied this question.