Why the study?
Can preclinical longitudinal trajectories of nEV biomarkers predict Alzheimer Disease diagnosis?
Can preclinical longitudinal trajectories of nEV biomarkers predict Alzheimer Disease diagnosis?
Preclinical longitudinal trajectories of nEV biomarkers can predict Alzheimer Disease diagnosis, motivating the development of a clinical blood test.
Hypothesis-generating for nEV biomarker trajectories in AD; prospective validation required before clinical adoption.
We validated nEV biomarker candidates and further demonstrated that their preclinical longitudinal trajectories can predict AD diagnosis. These findings motivate further development of nEV biomarkers toward a clinical blood test for AD.
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Kapogiannis et al. (2019) studied this question.
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