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September 8, 1998Circulation4,608 citations

Impact of Atrial Fibrillation on the Risk of Death

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EBEmelia J. BenjaminPWPhilip A. WolfRDRalph B. D’Agostino

Key Points

  • This research investigates the relationship between atrial fibrillation and mortality risk in a specific cohort.
  • Cohort study utilizing data from the Framingham Heart Study

Structured PICO

Does atrial fibrillation increase the risk of death in subjects from the Framingham Heart Study?

P
Population
Subjects from the original cohort of the Framingham Heart Study
I
Intervention
Atrial fibrillation (exposure)
C
Comparator
Absence of atrial fibrillation
O
Outcome
Mortality riskhard clinical

Atrial fibrillation is independently associated with a significant increase in mortality risk across both sexes and a wide range of ages.

Abstract

In subjects from the original cohort of the Framingham Heart Study, AF was associated with a 1.5- to 1.9-fold mortality risk after adjustment for the preexisting cardiovascular conditions with which AF was related. The decreased survival seen with AF was present in men and women and across a wide range of ages.

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Cite This Study

Benjamin et al. (1998) studied this question.

synapsesocial.com/papers/69daa2678988aeabbe687092https://doi.org/10.1161/01.cir.98.10.946
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic atrial fibrillation— epidemiologic features and 14 year follow-up: A case control study1987 · 190 citations
  2. 2Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study.1994 · 1,076 citations
  3. 3Longitudinal survey of ischaemic heart disease in randomly selected sample of older population.1977 · 71 citations
  4. 4Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study1994 · 2,929 citations
  5. 5Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials.1990 · 956 citations