Impact of Atrial Fibrillation on the Risk of Death

Emelia J. Benjamin; Philip A. Wolf; Ralph B. D’Agostino; Halit Silbershatz; William B. Kannel; Daniel Levy

doi:10.1161/01.cir.98.10.946

September 8, 1998Circulation

Impact of Atrial Fibrillation on the Risk of Death

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Why the study?

Does atrial fibrillation increase the risk of death in subjects from the Framingham Heart Study?

Key Points

This research investigates the relationship between atrial fibrillation and mortality risk in a specific cohort.
Cohort study utilizing data from the Framingham Heart Study
Analysis adjusted for preexisting cardiovascular conditions
Participants included both men and women across various ages.
Atrial fibrillation associated with 1.5- to 1.9-fold increased mortality risk.
Decreased survival observed in both genders and diverse age groups.

Structured PICO

Does atrial fibrillation increase the risk of death in subjects from the Framingham Heart Study?

P

Population

Subjects from the original cohort of the Framingham Heart Study

I

Intervention

Atrial fibrillation (exposure)

C

Comparator

Absence of atrial fibrillation

O

Outcome

Mortality riskhard clinical

Implication

Atrial fibrillation is independently associated with a significant increase in mortality risk across both sexes and a wide range of ages.

Abstract

In subjects from the original cohort of the Framingham Heart Study, AF was associated with a 1.5- to 1.9-fold mortality risk after adjustment for the preexisting cardiovascular conditions with which AF was related. The decreased survival seen with AF was present in men and women and across a wide range of ages.