Atrial Fibrillation and Mortality in Heart Failure
Key result
Atrial fibrillation prior to heart failure diagnosis was associated with a 29% increased risk of death, whereas developing AF after HF exhibited a >2-fold increased risk compared to no AF.
Why the study?
Does the timing of atrial fibrillation (prior to vs after HF diagnosis) influence the risk of all-cause mortality in patients with heart failure?
Population
1,664 individuals diagnosed with heart failure between 1983 and 2006 in a community-based cohort.
Comparison
Atrial fibrillation occurring prior to heart… vs Heart failure patients without atrial fibrillation
Design
Cohort
Follow-up
median 4.0 years
Authors
Discussion
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Member takes
Implication
AF timing may refine HF mortality stratification; leaves open whether timing-specific interventions improve outcomes.
Study Design
Type
Cohort (n=1,664)
Structured PICO
Does the timing of atrial fibrillation (prior to vs after HF diagnosis) influence the risk of all-cause mortality in patients with heart failure?
P
Population
1,664 individuals diagnosed with heart failure between 1983 and 2006 in a community-based cohort.
I
Intervention
Atrial fibrillation (AF) occurring prior to heart failure diagnosis or developing after heart failure diagnosis
C
Comparator
Heart failure patients without atrial fibrillation
O
Outcome
All-cause mortalityhard clinical
Main Result
Effect estimate: 29% increased risk
In patients with heart failure, developing atrial fibrillation after HF diagnosis confers a substantially higher (>2-fold) risk of death compared to having AF prior to HF diagnosis or no AF.
Cite This Study
Chamberlain et al. (2011) conducted a cohort in Heart failure and atrial fibrillation (n=1,664). Atrial fibrillation (prior to or after HF diagnosis) vs. No atrial fibrillation was evaluated on All-cause mortality (29% increased risk). Atrial fibrillation prior to heart failure diagnosis was associated with a 29% increased risk of death, whereas developing AF after HF exhibited a >2-fold increased risk compared to no AF.