Key result
Atrial fibrillation in patients with heart failure was associated with an increased risk of death compared to sinus rhythm in RCTs (OR 1.33; 95% CI 1.12-1.59) and observational studies.
Why the study?
Does atrial fibrillation increase the risk of death in patients with heart failure compared to sinus rhythm?
Population
32,946 patients with heart failure from 20 studies
Comparison
Atrial fibrillation (AF) vs Sinus rhythm (SR)
Design
Meta-analysis
Authors
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AF in HF signals higher mortality risk for closer monitoring; reinforces adverse prognostic link across RCTs and observational data.
Meta-Analysis (n=32,946)
Does atrial fibrillation increase the risk of death in patients with heart failure compared to sinus rhythm?
Effect estimate: OR 1.33 (95% CI 1.12-1.59)
Absolute Event Rate: 46% vs 33%
The presence of atrial fibrillation in patients with heart failure is associated with a significantly increased risk of mortality compared to those in sinus rhythm.
Wasywich et al. (2009) conducted a meta-analysis in Heart failure and atrial fibrillation (n=32,946). Atrial fibrillation vs. Sinus rhythm was evaluated on Death (OR 1.33, 95% CI 1.12-1.59). Atrial fibrillation in patients with heart failure was associated with an increased risk of death compared to sinus rhythm in RCTs (OR 1.33; 95% CI 1.12-1.59) and observational studies.
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