Why the study?
Heart failure and atrial fibrillation frequently coexist, but aggregate data comparing the risk profile of atrial fibrillation across HFrEF, HFmrEF, and HFpEF are lacking.
Does the presence of atrial fibrillation increase the risk of adverse outcomes in patients with HFrEF, HFmrEF, and HFpEF?
Population
248 323 patients across 22 studies with HFrEF, HFmrEF, and HFpEF
Comparison
AF vs no AF across HFrEF, HFmrEF, and HFpEF categories
Design
Systematic review and meta-analysis
Key result
Atrial fibrillation was associated with a higher risk of all-cause mortality (HR 1.25) and HF hospitalizations (HR 1.64) in patients with HFmrEF compared to HFrEF.
Authors
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Supports AF vigilance in HFmrEF; extends evidence on stronger prognostic links than in HFrEF.
Does the presence of atrial fibrillation increase the risk of adverse outcomes in patients with HFrEF, HFmrEF, and HFpEF?
Atrial fibrillation is associated with increased all-cause mortality and heart failure hospitalizations in patients with HFmrEF and HFpEF, but not in those with HFrEF.
Kroshian et al. (2024) studied this question. Atrial fibrillation was associated with a higher risk of all-cause mortality (HR 1.25) and HF hospitalizations (HR 1.64) in patients with HFmrEF compared to HFrEF.