Why the study?
Does atrial fibrillation worsen cardiovascular outcomes compared to sinus rhythm in patients with different ejection fraction subtypes of heart failure?
Population
14,964 patients with acute and chronic heart failure, mean age 66 ± 13 years, 67% male, from the European…
Comparison
Atrial fibrillation (AF) vs Sinus rhythm (SR)
Design
Cohort
Follow-up
up to ~2.2 years
Key result
Atrial fibrillation was associated with increased risk of all-cause death or HF hospitalization in patients with HFpEF (HR 1.365; 95% CI 1.152-1.619) and HFmrEF, but not HFrEF.
Authors
Loading...
May warrant closer monitoring in HFpEF/HFmrEF; leaves open whether rhythm control modifies outcomes.
Observational (n=14,964)
Yes
Does atrial fibrillation worsen cardiovascular outcomes compared to sinus rhythm in patients with different ejection fraction subtypes of heart failure?
Hazard Ratio: 1.365 (95% CI 1.152–1.619)
p-value: p=<0.001
Atrial fibrillation is associated with worse cardiovascular outcomes in patients with HFpEF and HFmrEF, but not in those with HFrEF.
Zafrir et al. (2018) conducted an observational in Heart failure (n=14,964). Atrial fibrillation vs. Sinus rhythm was evaluated on Combined all-cause death or HF hospitalizations in HFpEF (HR 1.365, 95% CI 1.152-1.619, p=<0.001). Atrial fibrillation was associated with increased risk of all-cause death or HF hospitalization in patients with HFpEF (HR 1.365; 95% CI 1.152-1.619) and HFmrEF, but not HFrEF.