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September 16, 2022ESC Heart FailureOpen Access

AF in HF patients is linked to ~29% annual mortality and increased acute hospitalization risk.

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Why the study?

The study was conducted to assess the bidirectional association between heart failure and atrial fibrillation using real-world data.

Does atrial fibrillation increase the risk of adverse clinical outcomes in patients with heart failure?

Population

128 086 patients with prevalent or incident HF from an electronic health recording database

Comparison

Patients with AF vs without AF

Design

Real-world electronic health records cohort study

Follow-up

5 years

Key result

Atrial fibrillation increased acute heart failure hospitalization risk to 97.5/1000 patients/year and all-cause mortality to 294/1000 patients/year in heart failure patients.

Authors

JDJavier DiazFMFernando MartínezJCJosé Miguel Calderón

Discussion

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Member takes

Overview

AF in HF signals need for vigilant follow-up; confirms elevated risks in large real-world cohorts.

Structured PICO

Does atrial fibrillation increase the risk of adverse clinical outcomes in patients with heart failure?

P
Population
128,086 adult patients with incident and prevalent heart failure (S1), including a subset of 57,354 patients with incident heart failure (S2), drawn from an electronic health record population of 3,799,885 subjects.
I
Intervention
Atrial fibrillation (AF) as an exposure
C
Comparator
Heart failure patients without atrial fibrillation
O
Outcome
Acute heart failure hospitalization, worsening renal function (eGFR reduced by >20%), ischaemic and haemorrhagic stroke, and all-cause mortalityhard clinical

In patients with heart failure, the presence of atrial fibrillation is associated with a significantly increased risk of acute heart failure hospitalization, renal decline, and all-cause mortality.

Cite This Study

Diaz et al. (2022) studied this question. Atrial fibrillation increased acute heart failure hospitalization risk to 97.5/1000 patients/year and all-cause mortality to 294/1000 patients/year in heart failure patients.

synapsesocial.com/papers/696688f3314faaf32ec7a4d7https://doi.org/10.1002/ehf2.14124
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of atrial fibrillation in patients with heart failure and reduced, mid-range or preserved ejection fraction2020 · 74 citations
  2. 2Impact of atrial fibrillation on long‐term clinical outcomes in outpatients with heart failure2013
  3. 3Newly Diagnosed Atrial Fibrillation and Hospital Utilization in Heart Failure: A Nationwide Cohort Study2021 · 5 citations
  4. 4Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14 964 patients in the European Society of Cardiology Heart Failure Long-Term Registry2018 · 298 citations
  5. 5Characterizing atrial fibrillation in patients with and without heart failure across the ejection fraction spectrum: Incidence, prevalence, and treatment strategies2024 · 8 citations