Low‐Dose Polystyrene Nanoplastics Alleviate High‐Fat Diet‐Induced Hepatic Injury via AMPK / mTOR ‐Mediated Lipophagy Activation

Key Points

• This research investigates how low-dose polystyrene nanoplastics affect liver health under a high-fat diet.
• Examined the effects of low-dose PS-NPs on liver injury in a high-fat diet context.
• Measured activation of the AMPK pathway and lipophagy processes.
• Analyzed the relationship between microplastics and dietary patterns in liver disease.
• Low-dose PS-NPs successfully activated the AMPK pathway and lipophagy.
• Processed liver injury was alleviated in high-fat diet conditions with PS-NP treatment.
• The study indicates a beneficial interaction between microplastics and metabolism in liver health.