July 28, 2005Open Access

Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis

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Abstract

Articular chondrocytes express functional RAGE. The increase in RAGE noted in OA cartilage and the ability of RAGE ligands to stimulate chondrocyte MAP kinase and NF-kappaB activity and to stimulate MMP-13 production suggests that chondrocyte RAGE signaling could play a role in OA.

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Cite This Study

Loeser et al. (Thu,) studied this question.

synapsesocial.com/papers/69deab8e6bae133e7de9493d https://doi.org/https://doi.org/10.1002/art.21199

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4In vivo selective inhibition of mitogen‐activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes2003 · 136 citations
5Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.1996 · 943 citations

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