Answers are grounded in this paper and cite their sources.
Articular chondrocytes express functional RAGE. The increase in RAGE noted in OA cartilage and the ability of RAGE ligands to stimulate chondrocyte MAP kinase and NF-kappaB activity and to stimulate MMP-13 production suggests that chondrocyte RAGE signaling could play a role in OA.
No takes yet. Share an insight, caveat, or question.
Loeser et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: