What question did this study set out to answer?

The aim is to develop an efficient method for N-arylation of ortho-acylanilines using mild conditions.

April 15, 2026Open Access

Development of Mild Palladium‐Catalyzed N‐Arylation of Ortho‐Acylanilines in Rhamnolipid Micellar System

Key Points

The aim is to develop an efficient method for N-arylation of ortho-acylanilines using mild conditions.
Utilized palladium-catalyzed reactions in a rhamnolipid micellar system.
Conducted reactions at 40°C to enhance efficiency.
Investigated broad substrate scope for the reactions.
Achieved high yields of N-arylated products at lower temperatures compared to conventional methods.
Demonstrated enhanced reactivity using the biodegradable surfactant system.
Showed potential for industrial applications and environmental benefits.

Abstract

We developed a green and efficient method for Pd-catalyzed N-arylation of ortho-acylanilines in water using rhamnolipid-based micellar catalysis. The (cinnamylPdCl)2/tBuXPhos system enables high yields at 40°C, significantly lower than conventional methods (>100°C), with broad substrate scope. This industrially produced biodegradable surfactant system offers a sustainable alternative to organic solvents, combining enhanced reactivity with improved energy efficiency and environmental compatibility.

Development of Mild Palladium‐Catalyzed N‐Arylation of Ortho‐Acylanilines in Rhamnolipid Micellar System

Key Points

Abstract

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