Green method improves N-arylation in ortho-acylanilines, suggesting a sustainable alternative to solvents.
We developed a green and efficient method for Pd-catalyzed N-arylation of ortho-acylanilines in water using rhamnolipid-based micellar catalysis. The (cinnamylPdCl)₂/tBuXPhos system enables high yields at 40°C, significantly lower than conventional methods (>100°C), with broad substrate scope. This industrially produced biodegradable surfactant system offers a sustainable alternative to organic solvents, combining enhanced reactivity with improved energy efficiency and environmental compatibility.
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Herczegh et al. (2026) studied this question.
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