What question did this study set out to answer?

The aim is to enhance thrombolytic therapy by developing targeted liposomes that respond to pH changes.

April 16, 2026Nanoscale1 citations

Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming

XLXinyuan LiChongqing University LCLingying ChenChongqing University RSRui SunChongqing University

Key Points

The aim is to enhance thrombolytic therapy by developing targeted liposomes that respond to pH changes.
Developed tLipo@UA liposomes targeting fibrin.
Tested the response of liposomes to varying pH levels.
Evaluated thrombolytic efficacy in thrombotic microenvironments.
tLipo@UA showed increased effectiveness in thrombus breakdown.
Demonstrated reduced bleeding risks compared to traditional therapies.
Exhibited significant reprogramming of the thrombotic microenvironment.

Abstract

Thrombolytic therapy, exemplified by tissue plasminogen activator, is often constrained by a short half-life, non-specific action, and bleeding risks. To address these limitations, we developed tLipo@UA, a fibrin-targeted and pH-responsive...

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